OK, I'm definitely not in the same boat as this guy. I'm lucky if I even get my rig apart once a month to clean out the bits. I do have this to say on the matter, though: air compressor. They're worth their weight in gold, & you can pick one up at Lowe's / Home Depot / wherever for ~$100. Seriously.

"For example, how many of you are guilty of dust cleansing fits? Do you systematically remove your computer case panels to dislodge the dusty bunnies when you notice your system temperature rises by 2 degrees? I’ve been known to clean each individual fin of my CPU heatsink with a Q-tip."